diff --git a/src/wp-admin/includes/media.php b/src/wp-admin/includes/media.php
index f9962827de..1060979e33 100644
--- a/src/wp-admin/includes/media.php
+++ b/src/wp-admin/includes/media.php
@@ -1780,6 +1780,12 @@ $plupload_init = array(
 	'multipart_params'    => $post_params,
 );
 
+// Currently only iOS Safari supports multiple files uploading but has a bug that prevents uploading of videos
+// when enabled. See #29602.
+if ( wp_is_mobile() ) {
+	$plupload_init['multi_selection'] = false;
+}
+
 /**
  * Filter the default Plupload settings.
  *
diff --git a/src/wp-includes/media.php b/src/wp-includes/media.php
index 4a0fa392a7..0f9b777477 100644
--- a/src/wp-includes/media.php
+++ b/src/wp-includes/media.php
@@ -2542,6 +2542,12 @@ function wp_plupload_default_settings() {
 		),
 	);
 
+	// Currently only iOS Safari supports multiple files uploading but has a bug that prevents uploading of videos
+	// when enabled. See #29602.
+	if ( wp_is_mobile() ) {
+		$defaults['multi_selection'] = false;
+	}
+
 	/**
 	 * Filter the Plupload default settings.
 	 *