diff --git a/src/js/_enqueues/admin/site-health.js b/src/js/_enqueues/admin/site-health.js
index 6211b1ea9f..d0e1b4cf89 100644
--- a/src/js/_enqueues/admin/site-health.js
+++ b/src/js/_enqueues/admin/site-health.js
@@ -15,6 +15,7 @@ jQuery( document ).ready( function( $ ) {
 	var data;
 	var clipboard = new ClipboardJS( '.site-health-copy-buttons .copy-button' );
 	var isDebugTab = $( '.health-check-body.health-check-debug-tab' ).length;
+	var pathsSizesSection = $( '#health-check-accordion-block-wp-paths-sizes' );
 
 	// Debug information copy section.
 	clipboard.on( 'success', function( e ) {
@@ -295,7 +296,7 @@ jQuery( document ).ready( function( $ ) {
 
 		copyButton.attr( 'data-clipboard-text', clipdoardText );
 
-		$( '#health-check-accordion-block-wp-paths-sizes' ).find( 'td[class]' ).each( function( i, element ) {
+		pathsSizesSection.find( 'td[class]' ).each( function( i, element ) {
 			var td = $( element );
 			var name = td.attr( 'class' );
 
@@ -306,6 +307,10 @@ jQuery( document ).ready( function( $ ) {
 	}
 
 	if ( isDebugTab ) {
-		getDirectorySizes();
+		if ( pathsSizesSection.length ) {
+			getDirectorySizes();
+		} else {
+			RecalculateProgression();
+		}
 	}
 } );
diff --git a/src/wp-admin/includes/ajax-actions.php b/src/wp-admin/includes/ajax-actions.php
index 3441945217..0f1f0f4e04 100644
--- a/src/wp-admin/includes/ajax-actions.php
+++ b/src/wp-admin/includes/ajax-actions.php
@@ -4967,7 +4967,7 @@ function wp_ajax_health_check_site_status_result() {
 function wp_ajax_health_check_get_sizes() {
 	check_ajax_referer( 'health-check-site-status-result' );
 
-	if ( ! current_user_can( 'install_plugins' ) ) {
+	if ( ! current_user_can( 'install_plugins' ) || is_multisite() ) {
 		wp_send_json_error();
 	}
 
diff --git a/src/wp-admin/includes/class-wp-debug-data.php b/src/wp-admin/includes/class-wp-debug-data.php
index f5e477589e..fe7fe60fef 100644
--- a/src/wp-admin/includes/class-wp-debug-data.php
+++ b/src/wp-admin/includes/class-wp-debug-data.php
@@ -109,10 +109,12 @@ class WP_Debug_Data {
 			),
 		);
 
-		$info['wp-paths-sizes'] = array(
-			'label'  => __( 'Directories and Sizes' ),
-			'fields' => array(),
-		);
+		if ( ! $is_multisite ) {
+			$info['wp-paths-sizes'] = array(
+				'label'  => __( 'Directories and Sizes' ),
+				'fields' => array(),
+			);
+		}
 
 		$info['wp-dropins'] = array(
 			'label'       => __( 'Drop-ins' ),
@@ -389,56 +391,59 @@ class WP_Debug_Data {
 			);
 		}
 
-		$loading = __( 'Loading…' );
+		// Remove accordion for Directories and Sizes if in Multisite.
+		if ( ! $is_multisite ) {
+			$loading = __( 'Loading…' );
 
-		$info['wp-paths-sizes']['fields'] = array(
-			'wordpress_path' => array(
-				'label' => __( 'WordPress directory location' ),
-				'value' => untrailingslashit( ABSPATH ),
-			),
-			'wordpress_size' => array(
-				'label' => __( 'WordPress directory size' ),
-				'value' => $loading,
-				'debug' => 'loading...',
-			),
-			'uploads_path'   => array(
-				'label' => __( 'Uploads directory location' ),
-				'value' => $upload_dir['basedir'],
-			),
-			'uploads_size'   => array(
-				'label' => __( 'Uploads directory size' ),
-				'value' => $loading,
-				'debug' => 'loading...',
-			),
-			'themes_path'    => array(
-				'label' => __( 'Themes directory location' ),
-				'value' => get_theme_root(),
-			),
-			'themes_size'    => array(
-				'label' => __( 'Themes directory size' ),
-				'value' => $loading,
-				'debug' => 'loading...',
-			),
-			'plugins_path'   => array(
-				'label' => __( 'Plugins directory location' ),
-				'value' => WP_PLUGIN_DIR,
-			),
-			'plugins_size'   => array(
-				'label' => __( 'Plugins directory size' ),
-				'value' => $loading,
-				'debug' => 'loading...',
-			),
-			'database_size'  => array(
-				'label' => __( 'Database size' ),
-				'value' => $loading,
-				'debug' => 'loading...',
-			),
-			'total_size'     => array(
-				'label' => __( 'Total installation size' ),
-				'value' => $loading,
-				'debug' => 'loading...',
-			),
-		);
+			$info['wp-paths-sizes']['fields'] = array(
+				'wordpress_path' => array(
+					'label' => __( 'WordPress directory location' ),
+					'value' => untrailingslashit( ABSPATH ),
+				),
+				'wordpress_size' => array(
+					'label' => __( 'WordPress directory size' ),
+					'value' => $loading,
+					'debug' => 'loading...',
+				),
+				'uploads_path'   => array(
+					'label' => __( 'Uploads directory location' ),
+					'value' => $upload_dir['basedir'],
+				),
+				'uploads_size'   => array(
+					'label' => __( 'Uploads directory size' ),
+					'value' => $loading,
+					'debug' => 'loading...',
+				),
+				'themes_path'    => array(
+					'label' => __( 'Themes directory location' ),
+					'value' => get_theme_root(),
+				),
+				'themes_size'    => array(
+					'label' => __( 'Themes directory size' ),
+					'value' => $loading,
+					'debug' => 'loading...',
+				),
+				'plugins_path'   => array(
+					'label' => __( 'Plugins directory location' ),
+					'value' => WP_PLUGIN_DIR,
+				),
+				'plugins_size'   => array(
+					'label' => __( 'Plugins directory size' ),
+					'value' => $loading,
+					'debug' => 'loading...',
+				),
+				'database_size'  => array(
+					'label' => __( 'Database size' ),
+					'value' => $loading,
+					'debug' => 'loading...',
+				),
+				'total_size'     => array(
+					'label' => __( 'Total installation size' ),
+					'value' => $loading,
+					'debug' => 'loading...',
+				),
+			);
+		}
 
 		// Get a list of all drop-in replacements.
 		$dropins = get_dropins();