diff --git a/src/wp-admin/includes/class-wp-ms-users-list-table.php b/src/wp-admin/includes/class-wp-ms-users-list-table.php
index e61ae97cbd..cd109e6c83 100644
--- a/src/wp-admin/includes/class-wp-ms-users-list-table.php
+++ b/src/wp-admin/includes/class-wp-ms-users-list-table.php
@@ -337,8 +337,25 @@ class WP_MS_Users_List_Table extends WP_List_Table {
 				continue;
 			}
 
-			$path = ( $val->path === '/' ) ? '' : $val->path;
-			echo '<span class="site-' . $val->site_id . '" >';
+			$path         = ( $val->path === '/' ) ? '' : $val->path;
+			$site_classes = array( 'site-' . $val->site_id );
+			/**
+			 * Filters the span class for a site listing on the mulisite user list table.
+			 *
+			 * @since 5.2.0
+			 *
+			 * @param array  $site_classes Class used within the span tag. Default "site-#" with the site's network ID.
+			 * @param int    $site_id      Site ID.
+			 * @param int    $network_id   Network ID.
+			 * @param object $user         WP_User object.
+			 */
+			$site_classes = apply_filters( 'ms_user_list_site_class', $site_classes, $val->userblog_id, $val->site_id, $user );
+			if ( is_array( $site_classes ) && ! empty( $site_classes ) ) {
+				$site_classes = array_map( 'sanitize_html_class', array_unique( $site_classes ) );
+				echo '<span class="' . sanitize_html_class( implode( ' ', $site_classes ) ) . '">';
+			} else {
+				echo '<span>';
+			}
 			echo '<a href="' . esc_url( network_admin_url( 'site-info.php?id=' . $val->userblog_id ) ) . '">' . str_replace( '.' . get_network()->domain, '', $val->domain . $path ) . '</a>';
 			echo ' <small class="row-actions">';
 			$actions         = array();