diff --git a/drivers/serial/Kconfig b/drivers/serial/Kconfig
index ffe1b3b6ff..b2b3b20a55 100644
--- a/drivers/serial/Kconfig
+++ b/drivers/serial/Kconfig
@@ -337,18 +337,7 @@ config 16550_ADDRWIDTH
 	---help---
 		The bit width of registers.  Options are 8, 16, or 32. Default: 8
 
-config 16550_THRNE
-	bool "Use THRNE"
-	default n if !ARCH_CHIP_MOXART
-	default y if ARCH_CHIP_MOXART
-	---help---
-		The 16550 UART has a bit in the line status register, THRE, that
-		indicates that the Transmit Holding Register (THR) is Empty (N).
-		This bit is inverted in at least one variant (the moxART SoC).
-		In that case, this setting must be included to use this bit as
-		THR *Not* Empty (THRNE).
-
-endif # 16550_UART
+endif
 
 #
 # MCU serial peripheral driver?
diff --git a/drivers/serial/uart_16550.c b/drivers/serial/uart_16550.c
index c88ea2b1af..5b7401c7a2 100644
--- a/drivers/serial/uart_16550.c
+++ b/drivers/serial/uart_16550.c
@@ -1030,11 +1030,7 @@ static void u16550_txint(struct uart_dev_s *dev, bool enable)
 static bool u16550_txready(struct uart_dev_s *dev)
 {
   struct u16550_s *priv = (struct u16550_s*)dev->priv;
-#ifdef CONFIG_16550_THRNE
-  return ((u16550_serialin(priv, UART_LSR_OFFSET) & UART_LSR_THRNE) == 0);
-#else
   return ((u16550_serialin(priv, UART_LSR_OFFSET) & UART_LSR_THRE) != 0);
-#endif
 }
 
 /****************************************************************************
@@ -1048,11 +1044,7 @@ static bool u16550_txready(struct uart_dev_s *dev)
 static bool u16550_txempty(struct uart_dev_s *dev)
 {
   struct u16550_s *priv = (struct u16550_s*)dev->priv;
-#ifdef CONFIG_16550_THRNE
-  return ((u16550_serialin(priv, UART_LSR_OFFSET) & UART_LSR_THRNE) == 0);
-#else
   return ((u16550_serialin(priv, UART_LSR_OFFSET) & UART_LSR_THRE) != 0);
-#endif
 }
 
 /****************************************************************************
@@ -1065,11 +1057,7 @@ static bool u16550_txempty(struct uart_dev_s *dev)
 
 static void u16550_putc(struct u16550_s *priv, int ch)
 {
-#ifdef CONFIG_16550_THRNE
-  while ((u16550_serialin(priv, UART_LSR_OFFSET) & UART_LSR_THRNE) == 0);
-#else
-  while ((u16550_serialin(priv, UART_LSR_OFFSET) & UART_LSR_THRE) != 0);
-#endif
+  while ((u16550_serialin(priv, UART_LSR_OFFSET) & UART_LSR_THRE) == 0);
   u16550_serialout(priv, UART_THR_OFFSET, (uart_datawidth_t)ch);
 }
 
diff --git a/include/nuttx/serial/uart_16550.h b/include/nuttx/serial/uart_16550.h
index 8980949d6a..de37fb5502 100644
--- a/include/nuttx/serial/uart_16550.h
+++ b/include/nuttx/serial/uart_16550.h
@@ -299,11 +299,7 @@
 #define UART_LSR_PE                  (1 << 2)  /* Bit 2:  Parity Error */
 #define UART_LSR_FE                  (1 << 3)  /* Bit 3:  Framing Error */
 #define UART_LSR_BI                  (1 << 4)  /* Bit 4:  Break Interrupt */
-#ifdef CONFIG_16550_THRNE
-#  define UART_LSR_THRNE             (1 << 5)  /* Bit 5:  Transmitter Holding Register Not Empty */
-#else
-#  define UART_LSR_THRE              (1 << 5)  /* Bit 5:  Transmitter Holding Register Empty */
-#endif
+#define UART_LSR_THRE                (1 << 5)  /* Bit 5:  Transmitter Holding Register Empty */
 #define UART_LSR_TEMT                (1 << 6)  /* Bit 6:  Transmitter Empty */
 #define UART_LSR_RXFE                (1 << 7)  /* Bit 7:  Error in RX FIFO (RXFE) */