diff --git a/arch/arm/src/s32k1xx/s32k1xx_lpi2c.c b/arch/arm/src/s32k1xx/s32k1xx_lpi2c.c
index 367d4644a6..fbe22edddb 100644
--- a/arch/arm/src/s32k1xx/s32k1xx_lpi2c.c
+++ b/arch/arm/src/s32k1xx/s32k1xx_lpi2c.c
@@ -454,8 +454,9 @@ s32k1xx_lpi2c_modifyreg(struct s32k1xx_lpi2c_priv_s *priv,
 #ifdef CONFIG_S32K1XX_LPI2C_DYNTIMEO
 static uint32_t s32k1xx_lpi2c_toticks(int msgc, struct i2c_msg_s *msgs)
 {
-  size_t bytecount = 0;
   int i;
+  size_t bytecount = 0;
+  uint32_t tick    = 0;
 
   /* Count the number of bytes left to process */
 
@@ -465,10 +466,16 @@ static uint32_t s32k1xx_lpi2c_toticks(int msgc, struct i2c_msg_s *msgs)
     }
 
   /* Then return a number of microseconds based on a user provided scaling
-   * factor.
+   * factor. It must not be 0.
    */
 
-  return USEC2TICK(CONFIG_S32K1XX_LPI2C_DYNTIMEO_USECPERBYTE * bytecount);
+  tick = USEC2TICK(CONFIG_S32K1XX_LPI2C_DYNTIMEO_USECPERBYTE * bytecount);
+  if (tick == 0)
+    {
+      tick = 1;
+    }
+
+  return tick;
 }
 #endif