diff --git a/net/sixlowpan/README.txt b/net/sixlowpan/README.txt
index ca8a513d6a..5b6b4e298d 100644
--- a/net/sixlowpan/README.txt
+++ b/net/sixlowpan/README.txt
@@ -49,7 +49,7 @@ The length of the fragment header length is four bytes for the first header
 (FRAG1) and five bytes for all subsequent headers (FRAGN).  For example,
 this is a HC1 compressed first frame of a packet
 
-  41 88 01 cefa 3412 cdab                       ### 9-byte MAC header
+  41 88 2a cefa 3412 cdab                       ### 9-byte MAC header
   c50e 000b                                     ### 4-byte FRAG1 header
   42                                            ### SIXLOWPAN_DISPATCH_HC1
     fb                                          ### RIME_HC1_HC_UDP_HC1_ENCODING
@@ -66,7 +66,7 @@ this is a HC1 compressed first frame of a packet
 
 This is the second frame of the same transfer:
 
-  41 88 01 cefa 3412 cdab                       ### 9-byte MAC header
+  41 88 2b cefa 3412 cdab                       ### 9-byte MAC header
   e50e 000b 0d                                  ### 5 byte FRAGN header
   42                                            ### SIXLOWPAN_DISPATCH_HC1
     fb                                          ### RIME_HC1_HC_UDP_HC1_ENCODING
diff --git a/net/sixlowpan/sixlowpan_framelist.c b/net/sixlowpan/sixlowpan_framelist.c
index c9985872ba..9f7a68a1f7 100644
--- a/net/sixlowpan/sixlowpan_framelist.c
+++ b/net/sixlowpan/sixlowpan_framelist.c
@@ -281,7 +281,7 @@ int sixlowpan_queue_frames(FAR struct ieee802154_driver_s *ieee,
 
   ninfo("Sending packet length %d\n", buflen);
 
-  /* Set the source and destinatino address */
+  /* Set the source and destination address */
 
   rimeaddr_copy(&g_pktaddrs[PACKETBUF_ADDR_SENDER],
                 &ieee->i_dev.d_mac.ieee802154);
@@ -348,7 +348,9 @@ int sixlowpan_queue_frames(FAR struct ieee802154_driver_s *ieee,
       ninfo("Sending fragmented packet length %d\n", buflen);
 
       /* Create 1st Fragment */
-      /* Add the frame header using the pre-allocated IOB. */
+      /* Add the frame header using the pre-allocated IOB using the DSN
+       * selected by sixlowpan_send_hdrlen().
+       */
 
       verify = sixlowpan_framecreate(ieee, iob, ieee->i_panid);
       DEBUGASSERT(verify == framer_hdrlen);
@@ -434,11 +436,17 @@ int sixlowpan_queue_frames(FAR struct ieee802154_driver_s *ieee,
           iob->io_pktlen = 0;
           fptr           = iob->io_data;
 
-          /* Copy the frame header at the beginning of the frame. */
+          /* Add a new frame header to the IOB (same as the first but with a
+           * different DSN).
+           */
 
-          memcpy(fptr, frame1, framer_hdrlen);
+          g_pktattrs[PACKETBUF_ATTR_MAC_SEQNO] = 0;
 
-          /* Move HC1/HC06/IPv6 header the frame header from first
+          verify = sixlowpan_framecreate(ieee, iob, ieee->i_panid);
+          DEBUGASSERT(verify == framer_hdrlen);
+          UNUSED(verify);
+
+          /* Copy the HC1/HC06/IPv6 header the frame header from first
            * frame, into the correct location after the FRAGN header
            * of subsequent frames.
            */
diff --git a/net/sixlowpan/sixlowpan_framer.c b/net/sixlowpan/sixlowpan_framer.c
index 13aa9fecd3..da52303c6c 100644
--- a/net/sixlowpan/sixlowpan_framer.c
+++ b/net/sixlowpan/sixlowpan_framer.c
@@ -322,12 +322,12 @@ static void sixlowpan_setup_params(FAR struct ieee802154_driver_s *ieee,
 
   if (g_pktattrs[PACKETBUF_ATTR_MAC_SEQNO] != 0)
     {
-      params->seq = g_pktattrs[PACKETBUF_ATTR_MAC_SEQNO];
+      params->seq = g_pktattrs[PACKETBUF_ATTR_MAC_SEQNO] & 0xff;
     }
   else
     {
       params->seq = ieee->i_dsn++;
-      g_pktattrs[PACKETBUF_ATTR_MAC_SEQNO] = params->seq;
+      g_pktattrs[PACKETBUF_ATTR_MAC_SEQNO] = params->seq | 0x100;
     }
 
   /* Complete the addressing fields. */
diff --git a/wireless/ieee802154/mac802154_loopback.c b/wireless/ieee802154/mac802154_loopback.c
index af1320fccf..f914b5db1a 100644
--- a/wireless/ieee802154/mac802154_loopback.c
+++ b/wireless/ieee802154/mac802154_loopback.c
@@ -618,6 +618,10 @@ int ieee8021514_loopback(void)
 
   priv->lo_polldog = wd_create(); /* Create periodic poll timer */
 
+  /* Initialize the DSN to a "random" value */
+
+  priv->lo_ieee.i_dsn = 42;
+
   /* Register the loopabck device with the OS so that socket IOCTLs can b
    * performed.
    */