diff -uNr Python-3.6.2/Lib/aifc.py Python-3.6.2.mod/Lib/aifc.py
--- Python-3.6.2/Lib/aifc.py	2017-07-08 06:33:27.000000000 +0300
+++ Python-3.6.2.mod/Lib/aifc.py	2017-09-15 15:09:08.092797061 +0300
@@ -920,7 +920,7 @@
 if __name__ == '__main__':
     import sys
     if not sys.argv[1:]:
-        sys.argv.append('/usr/demos/data/audio/bach.aiff')
+        sys.argv.append('@TERMUX_PREFIX@/demos/data/audio/bach.aiff')
     fn = sys.argv[1]
     with open(fn, 'r') as f:
         print("Reading", fn)
diff -uNr Python-3.6.2/Lib/mailcap.py Python-3.6.2.mod/Lib/mailcap.py
--- Python-3.6.2/Lib/mailcap.py	2017-07-08 06:33:27.000000000 +0300
+++ Python-3.6.2.mod/Lib/mailcap.py	2017-09-15 15:08:41.312797081 +0300
@@ -55,7 +55,8 @@
             # Don't bother with getpwuid()
             home = '.' # Last resort
         mailcaps = [home + '/.mailcap', '/etc/mailcap',
-                '/usr/etc/mailcap', '/usr/local/etc/mailcap']
+                '/usr/etc/mailcap', '/usr/local/etc/mailcap',
+                '@TERMUX_PREFIX@/etc/mailcap']
     return mailcaps
 
 
diff -uNr Python-3.6.2/Lib/mimetypes.py Python-3.6.2.mod/Lib/mimetypes.py
--- Python-3.6.2/Lib/mimetypes.py	2017-07-08 06:33:27.000000000 +0300
+++ Python-3.6.2.mod/Lib/mimetypes.py	2017-09-15 15:08:05.522797106 +0300
@@ -49,6 +49,7 @@
     "/usr/local/lib/netscape/mime.types",
     "/usr/local/etc/httpd/conf/mime.types",     # Apache 1.2
     "/usr/local/etc/mime.types",                # Apache 1.3
+    "@TERMUX_PREFIX@/etc/mime.types",           # Termux
     ]
 
 inited = False
diff -uNr Python-3.6.2/Lib/posixpath.py Python-3.6.2.mod/Lib/posixpath.py
--- Python-3.6.2/Lib/posixpath.py	2017-07-08 06:33:27.000000000 +0300
+++ Python-3.6.2.mod/Lib/posixpath.py	2017-09-15 15:07:20.872797138 +0300
@@ -32,7 +32,7 @@
 extsep = '.'
 sep = '/'
 pathsep = ':'
-defpath = '/bin:/usr/bin'
+defpath = '@TERMUX_PREFIX@/bin:@TERMUX_PREFIX@/bin/applets'
 altsep = None
 devnull = '/dev/null'
 
diff -uNr Python-3.6.2/Lib/uuid.py Python-3.6.2.mod/Lib/uuid.py
--- Python-3.6.2/Lib/uuid.py	2017-07-08 06:33:27.000000000 +0300
+++ Python-3.6.2.mod/Lib/uuid.py	2017-09-15 15:06:36.372797170 +0300
@@ -306,7 +306,7 @@
     import os, shutil, subprocess
     executable = shutil.which(command)
     if executable is None:
-        path = os.pathsep.join(('/sbin', '/usr/sbin'))
+        path = os.pathsep.join(('@TERMUX_PREFIX@/bin', '@TERMUX_PREFIX@/bin/applets'))
         executable = shutil.which(command, path=path)
         if executable is None:
             return None