diff -uNr Python-2.7.13/Lib/aifc.py Python-2.7.13.mod/Lib/aifc.py
--- Python-2.7.13/Lib/aifc.py	2016-12-17 22:05:05.000000000 +0200
+++ Python-2.7.13.mod/Lib/aifc.py	2017-09-15 14:39:33.972798330 +0300
@@ -960,7 +960,7 @@
 if __name__ == '__main__':
     import sys
     if not sys.argv[1:]:
-        sys.argv.append('/usr/demos/data/audio/bach.aiff')
+        sys.argv.append('@TERMUX_PREFIX@/demos/data/audio/bach.aiff')
     fn = sys.argv[1]
     f = open(fn, 'r')
     try:
diff -uNr Python-2.7.13/Lib/mailcap.py Python-2.7.13.mod/Lib/mailcap.py
--- Python-2.7.13/Lib/mailcap.py	2016-12-17 22:05:06.000000000 +0200
+++ Python-2.7.13.mod/Lib/mailcap.py	2017-09-15 14:48:24.432797951 +0300
@@ -44,7 +44,8 @@
             # Don't bother with getpwuid()
             home = '.' # Last resort
         mailcaps = [home + '/.mailcap', '/etc/mailcap',
-                '/usr/etc/mailcap', '/usr/local/etc/mailcap']
+                '/usr/etc/mailcap', '/usr/local/etc/mailcap',
+                '@TERMUX_PREFIX@/etc/mailcap']
     return mailcaps
 
 
diff -uNr Python-2.7.13/Lib/mimetypes.py Python-2.7.13.mod/Lib/mimetypes.py
--- Python-2.7.13/Lib/mimetypes.py	2016-12-17 22:05:06.000000000 +0200
+++ Python-2.7.13.mod/Lib/mimetypes.py	2017-09-15 14:22:15.642799073 +0300
@@ -47,6 +47,7 @@
     "/usr/local/lib/netscape/mime.types",
     "/usr/local/etc/httpd/conf/mime.types",     # Apache 1.2
     "/usr/local/etc/mime.types",                # Apache 1.3
+    "@TERMUX_PREFIX@/etc/mime.types",           # Termux
     ]
 
 inited = False
diff -uNr Python-2.7.13/Lib/posixpath.py Python-2.7.13.mod/Lib/posixpath.py
--- Python-2.7.13/Lib/posixpath.py	2016-12-17 22:05:06.000000000 +0200
+++ Python-2.7.13.mod/Lib/posixpath.py	2017-09-15 14:47:13.762798002 +0300
@@ -32,7 +32,7 @@
 extsep = '.'
 sep = '/'
 pathsep = ':'
-defpath = ':/bin:/usr/bin'
+defpath = ':@TERMUX_PREFIX@/bin'
 altsep = None
 devnull = '/dev/null'
 
diff -uNr Python-2.7.13/Lib/uuid.py Python-2.7.13.mod/Lib/uuid.py
--- Python-2.7.13/Lib/uuid.py	2016-12-17 22:05:06.000000000 +0200
+++ Python-2.7.13.mod/Lib/uuid.py	2017-09-15 14:46:19.442798040 +0300
@@ -296,7 +296,7 @@
 def _popen(command, args):
     import os
     path = os.environ.get("PATH", os.defpath).split(os.pathsep)
-    path.extend(('/sbin', '/usr/sbin'))
+    path.extend(['@TERMUX_PREFIX@/bin'])
     for dir in path:
         executable = os.path.join(dir, command)
         if (os.path.exists(executable) and