Submitted upstream: https://github.com/erlang/otp/pull/1861

diff -u -r ../otp-OTP-21.0.1/erts/configure.in ./erts/configure.in
--- ../otp-OTP-21.0.1/erts/configure.in	2018-06-25 13:19:47.000000000 +0200
+++ ./erts/configure.in	2018-07-01 17:57:13.738522618 +0200
@@ -581,7 +581,8 @@
            PROFILE_INSTR_USE=false])
         rm -f default.profdata
       fi],
-     [])
+     [],
+     [AC_MSG_NOTICE([Disabling PGO when cross-compiling])])
    rm -f *.profraw
    CFLAGS=$saved_CFLAGS;
 fi